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KMID : 0859320070250020070
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Journal of the Korean Society for Therapeutic Radiology and Oncology
2007 Volume.25 No. 2 p.70 ~ p.78
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Bladder Preserving Treatment in Patients with Muscle Invasive Bladder Cancer
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Yu Jeong-Il
Lim Ho-Yeong
Choi Han-Yong
Huh Seung-Jae
Ahn Yong-Chan
Lee Hyun-Moo
Kim Won-Seog
Park Won
Oh Dong-Ryol
Jeon Seong-Soo
Lim Do-Hoon
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Abstract
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Purpose: This study analyzed the tumor response, overall survival, progression free survival and related prognostic factors in patients with muscle invasive bladder cancer subjected to bladder preserving treatment.
Materials and Methods: Between August 1995 and June 2004, 37 patients with muscle invasive (transitional cell carcinoma, clinically stage T2-4) bladder cancer were enrolled for the treatment protocol of bladder preservation. There were 33 males and 4 females, and the median age was 67 years (range 38∼86 years). Transurethral resection of the bladder (TURB) was performed in 17 patients who underwent complete resection. The median radiation dose administered was 64.8 Gy (range 55.8∼67 Gy). The survival rate was calculated by the Kaplan-Meier method.
Results: An evaluation of the response rate was determined by abdomen-pelvic CT and cystoscopy at three months after radiotherapy. A complete response was seen in 17 patients (46%). The survival rate at three years was 54.7%, with 54 months of median survival (range 3∼91 months). During the study, 17 patients died and 13 patients had died from bladder cancer. The progression free survival rate at three years was 37.2%. There were 24 patients (64.9%) who had disease recurrence: 16 patients (43.2%) had local recurrence, 6 patients (16.2%) had a distant recurrence, and 2 patients (5.4%) had both a local and distant recurrence. The survival rate (p=0.0009) and progression free survival rates (p=0.001) were statistically significant when compared to the response rate after radiotherapy.
Conclusion: The availability of complete TURB and appropriate chemoradiotherapy were important predictors for bladder preservation and survival.
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KEYWORD
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Bladder cancer, Bladder preserving teratment, Radiotherapy
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